Una risposta naturale ai disturbi dell’umore.
GRIFFONIA DREAM/MOOD
A Natural Responses to mood disorders
GRIFFONIA DREAM
CLINICAL APPLICATIONS
Sleep troubles
It is proved that 5-HTP is useful also in the treatment of sleep troubles.
Administrations in adults and children of L-5HTP showed and improvement of sleep troubles, for a correlation between serotonin, sleep quality and REM phaset.
USE MODALITY
1-2 capsules before sleeping.
Children: 1 capsule before sleeping.
COMPOSITION:
Griffonia seeds d.e. (equal to 100 mg of 5-HTP); Passionflower d.e. (5 mg of Vitexin).
GRIFFONIA MOOD
CLINICAL APPLICATIONS:
Obesity and Depression
The antidepressive efficacy of 5-HTP has been studied in more than 500 patients
treated for a period from 4 weeks to 8 months, and it has been pointed out a
reduction of depressive intensity and symptoms.
A significant improvement was seen in 70 % of treated patients.
USE MODALITY
1 capsule two times a day.
MAINTENANCE
Gradually it can be increased until 3-6 capsules a day.
This dosage allows also a reduction of appetite, with an obvious consequent aid in particular cases of obesity.
COMPOSITION:
Griffonia seeds d.e. (equal to 100 mg of 5-HTP); Vitamin B6 hydrochloride
Griffonia Simplicifolia,
Griffonia Simplicifolia is a plant that grows in regions of West Africa: Ghana, Ivory cost and Togo, it was used already in ancient African Tradition:
– the bark and the root like stick to chew;
– the leaves to heal the wounds,
– the juice as enema and for the treatment of renal troubles;
– the leaves’ decoction against vomiting and as aphrodisiac;
– the bark’s mush like plaster on shallow injuries.
Studies conducted from 1960 on the seeds of this Leguminous, showed the presence of different derivative indoles:
– 5-hydroxy-levo-tryptophan
– Indole -3-acetylaspartate Acid
– 5-hydroxy-indole-3-acetic Acid.
The discovery of so high concentrations of L-5-HTP makes the Griffonia a rich source of 5-HTP.
The 5-hydroxytriptophan, L-a- amino-b acid (5- rossiindolil)-propionic Acid, comes
from tryptophan, essential amino acid, known as the precursor of hydroxytryptamine, or serotonin (5-HT); more precisely the 5-HTP is the intermediate step of tryptophan’s
transformation in serotonin.
TOXICOLOGICAL INFORMATIONS and SIDE EFFECTS.
Toxicological studies have shown, against 5-HTP, negligible values regards to therapeutic doses; in fact, in mice they have shown a DL50 per os equal to 2500 mg/kg, while the DL50 i.p. was resulted equal to 1400mg/Kg; no teratogenic activity in mice and rabbit.
As side effects, the administration of L- 5HTP can induce nausea, occasionally vomiting and other gastrointestinal troubles that generally diminish or even disappear after the stabilization of dosage.
Serotonin
Serotonin plays a significant role as neuromediator in the regulation of a lot of activities at level of Central Nervous System:
• the control of pain’s threshold,
• induction of sleep,
• regulation of pituitary-endocrine activity,
• neuronal excitability,
• thermoregulation,
• appetite,
• sexual behavior,
• aggression.
A lot of studies have demonstrated that an increase of serotonin levels brings to increase the mood tone, decrease of appetite, sleep improvement.
Vice versa, depressive syndromes occur, in most cases, due to a lack of serotonin in certain brain synaptic clefts.
An increased level of serotonin can be obtained in a more natural way increasing the level of endogenous precursor of hydroxytriptamine, as L-5-HTP, which has resulted, from numerous studies conducted between 1970 and 1980, to be more powerful than synthetic
antidepressant tricyclic drugs.
This would also prevent many side effects that the SSRI, like most drugs, cause to our organism.
Gabryel B., Trzeciak H.I., Nootropics: Pharmacological properties and therapeutic use, Polish Journal of Pharmacology, 1994.
Hüner N.P.A., Hopkins W.G., Fisiologia vegetale, McGraw Hill, 2008
McBurney R., African Wild Harvest, Royal Botanic Gardens, Kew, 2004
Petkov V.D., Getova D., Mosharrof A.H., A study of nootropic drugs for anti-anxiety action, Institute of Physiology, Bulgarian Academy of Sciences, Sofia. Acta Physiol Pharmacol Bulg, January 1, 1987.
Scarpa A., Etnomedicina. Verità scientifiche, strane credenze e singolari terapie, meritevoli di verifica, delle medicine tradizionali dei popoli, Ed. Lucisano, Milano, 1981.
Singh H.K., Dhawan B.N., Neuropsychopharmacological effects of the Ayurved nootropic Bacopa monniera Linn. (Brahmi), Indian Journal of Pharmacology Vol: 29.
Stancheva S.L., Petkov V.D., Hadjiivanova C.I., Petkov V.V., Age-related changes of the effects of a group of nootropic drugs on the content of rat brain biogenic monoamines, Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia. Gen Pharmacol, January 1, 1991. 1981